The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients with COVID-19: A randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Microbial pathogenesis [Category] SARS, 바이오마커, [키워드] ALP assigned baseline body temperature can be used clinical clinical trial Clinical trial study control group COVID-19 COVID-19 disease COVID-19 disease severity CPK CRP determine dimer disease severity Effect effective ELISA kit ESR IL-6 immune system IMPROVE Intervention intervention group Iran laboratory biomarker laboratory biomarkers laboratory parameter LDH lymphocyte Lymphocyte count nutrition Nutrition bio-shield superfood. oxygen saturation Patient patients with COVID-19 performed Placebo Randomized randomized clinical trial receiving Result Serum level serum sample SGOT SGPT significant decrease significant increase single-blind Superfood Tehran tested the mean TNF-α Treatment Trial two group Two-arm variable was performed WBC [DOI] 10.1016/j.micpath.2022.105792 PMC 바로가기
Conformational ensemble of the full-length SARS-CoV-2 nucleocapsid (N) protein based on molecular simulations and SAXS data분자 시뮬레이션 및 SAXS 데이터를 기반으로 한 전장 SARS-CoV-2 뉴클레오캡시드(N) 단백질의 구조적 앙상블Article Published on 2022-09-012022-09-11 Journal: Biophysical chemistry [Category] COVID19(2023년), SARS, 치료법, [키워드] average conditions conformation conformational conformations Contact dimer domain domains Each EROS exhibit experiment fluctuation full-length full-length SARS-CoV-2 gyration hydrophobic intrinsically knowledge Molecular simulation NMR nonspecific nucleocapsid nucleocapsid protein offer Protein radius of gyration Region SARS-CoV-2 SARS-CoV-2 virus SAXS. Structure structures the SARS-CoV-2 virus while X-ray scattering α-helix [DOI] 10.1016/j.bpc.2022.106843 PMC 바로가기 [Article Type] Article
The prognostic value of biomarker levels and chest imaging in patients with COVID-19 presenting to the emergency department응급실에 제출하는 COVID-19 환자의 바이오마커 수치 및 흉부 영상의 예후 가치Article Published on 2022-09-012022-09-11 Journal: The American journal of emergency medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95% CI age AUC Biomarker Biomarkers C-reactive protein Care Chain Reaction Chest CT chest imaging COVID-19 COVID-19 patient COVID-19 patients CRP D-dimer Department dimer Emergency emergency department ferritin Hospital mortality ICU admission in-hospital mortality Laboratory parameters Lactate lactate dehydrogenase LDH Logistic regression Lung imaging lymphocyte mechanical ventilation Mortality Natriuretic neutrophil Neutrophil to lymphocyte ratio. neutrophil/lymphocyte ratio NLR not performed obesity Patient patients with COVID-19 peptide performed polymerase chain polymerase chain reaction positive presenting Primary outcome procalcitonin prognostic Prognostic value Quantitative real-time reverse transcriptase retrospective reverse transcriptase Reverse transcriptase polymerase chain reaction severity significantly tested troponin vital sign [DOI] 10.1016/j.ajem.2022.06.043 PMC 바로가기 [Article Type] Article
Discrepancy between biomarkers of lung injury and 1-year mortality in COVID-19COVID-19에서 폐 손상의 바이오마커와 1년 사망률 간의 불일치Observational Study Published on 2022-09-012022-09-11 Journal: European Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] 95% CI Accuracy analysis association AUC Biomarker Biomarkers C-reactive protein cardiac troponin Chain Reaction COVID-19 COVID-19 pneumonia cross-sectional CRP CT severity score cTn cut-off cut-off value D-dimer determine dimer evaluated ferritin First wave global pandemic highest Lactate lactate dehydrogenase LDH Linear regression analysis Lung injury lymphocyte Mortality mortality. multivariate multivariate analyses neutrophil Neutrophil-to-lymphocyte ratio NLR observational study parameter Patient performed Pneumonia polymerase chain polymerase chain reaction predict predicted Predictive predictor regression analysis SARS-CoV-2 sensitivity severe lung injury severity severity of COVID-19 specificity tomography uric acid was used [DOI] 10.1111/eci.13827 PMC 바로가기 [Article Type] Observational Study
Risks of catching COVID-19 according to vaccination status of healthcare workers during the SARS-CoV-2 Delta variant dominant period and their clinical characteristicsSARS-CoV-2 Delta 변종 우세 기간 동안 의료 종사자의 예방 접종 상태 및 임상 특성에 따른 COVID-19 감염 위험Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 BioNTech C-reactive protein Clinical characteristics Clinical course CoronaVac coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 transmission CRP D-dimer delta variant dimer dominant dose ferritin HCW HCWs healthcare healthcare worker Healthcare workers healthcare workers. Hospitalization investigated lowest lymphocyte Lymphocyte count Not needed pandemic Patient patients patients with COVID-19 required SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly higher statistically significant status the disease the SARS-CoV-2 training transmission rate Turkey vaccination Vaccination Status Vaccine [DOI] 10.1002/jmv.27778 PMC 바로가기 [Article Type] Article
The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19코로나19의 산화 스트레스 지수와 내피 기능 장애에 대한 알로퓨리놀의 전향적 효과Article Published on 2022-08-012022-09-11 Journal: Inflammation [Category] COVID19(2023년), SARS, 바이오마커, [키워드] addition Admission allopurinol antioxidant Biomarker Biomarkers clinical outcomes cohort study correlated COVID-19 patients COVID-19 severity CRP CT scan Cytokines Cytopathic effect D-dimer dimer discharge Effect endothelial Endothelial dysfunction Endothelin Endothelin-1 enzyme ET-1 evaluated ferritin Gout Hospitalization index Inflammatory Inflammatory biomarker inflammatory biomarkers inflammatory disorder inflammatory disorders inflammatory disorders. inflammatory reaction LDH lymphocyte metabolism neutrophil NLR oxidative oxidative stress oxidative stress. Patient pro-inflammatory cytokine pro-inflammatory cytokines procalcitonin procalcitonin) Propagation Prospective protective effect purine recruited reduced reported SARS-CoV-2 Serum level severe COVID-19 severe COVID-19 patients severity significantly single-center Standard therapy standard treatment standard treatment alone three groups Treatment triggered uric acid Viral viral infections xanthine [DOI] 10.1007/s10753-022-01648-7 PMC 바로가기 [Article Type] Article
Evaluation of a potential prognostic parameter for the inflammatory status in COVID-19 patients: The inflammatory protein ratioCOVID-19 환자의 염증 상태에 대한 잠재적인 예후 매개변수 평가: 염증 단백질 비율Article Published on 2022-08-012022-09-11 Journal: Electrophoresis [Category] COVID19(2023년), SARS, 치료기술, [키워드] albumin all the patients ANOVA C-reactive protein calculated Chain Reaction controls coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient CRP D-dimer dimer fibrinogen Globulin hospitalized patient Human plasma immuno-turbidimetric assay immunoassay Inflammatory inflammatory protein inflammatory state inflammatory status Interpretation involved Kruskal-Wallis mathematical Nasopharyngeal swab nasopharyngeal swabs parameter parameters Pearson performed polymerase chain polymerase chain reaction prognostic proportionality Protein qualitative test quantified real time real time Polymerase Chain Reaction RNA RT-PCR SARS-CoV-2 SARS-CoV-2 positivity separated Serum protein serum protein electrophoresis. serum proteins Significant significantly Spearman the patient unique variance [DOI] 10.1002/elps.202100396 PMC 바로가기 [Article Type] Article
Long-Term Outcomes after Vaccine-Induced Thrombotic Thrombocytopenia백신 유도성 혈전성 혈소판 감소증 후 장기 결과Article Published on 2022-08-012022-09-11 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] acute phase Adenovirus adenovirus-based affected antibody Anticoagulants anticoagulation appear Arterial thrombosis AZD1222 bleeding cerebral venous sinus thrombosis ChAdOx1 ChAdOx1 nCoV-19 Cohort Cohort studies cohort study Complication coronavirus Corticosteroids COVID-19 D-dimer detectable diagnosed Diagnosis died dimer Direct discharge discharged eculizumab effective elevated enrolled Follow-up hospital hospital discharge Immunoglobulin in some Intravenous immunoglobulin IVIG limit management nCoV neurological nine observation occurred one patient oral anticoagulant outcome Patient patients PF4 Platelet platelet activation positive prothrombotic condition remained respiratory respiratory syndrome coronavirus respiratory syndrome coronavirus 2 Safe SARS-CoV-2 serious complication Seven severe respiratory syndrome single-center Sinus thrombosis survived Symptom symptom onset syndrome the disease thrombocytopenia thromboembolic Thromboembolic event Thromboembolic events thrombosis thrombotic Thrombotic thrombocytopenia Treatment two patients vaccination vaccination. Vaccine venous venous sinus were given [DOI] 10.3390/v14081702 PMC 바로가기 [Article Type] Article
Effect of pH on stability of dimer structure of the main protease of coronavirus-2Article Published on 2022-08-012023-07-09 Journal: Biophysical chemistry [Category] COVID19(2023년), [키워드] coronavirus dimer M(pro) main protease molecular dynamics pH effect. [DOI] 10.1016/j.bpc.2022.106829 PMC 바로가기
The usefulness of D-dimer as a predictive marker for mortality in patients with COVID-19 hospitalized during the first wave in Italy이탈리아의 첫 번째 물결 동안 입원한 COVID-19 환자의 사망률에 대한 예측 마커로서 D-dimer의 유용성Article Published on 2022-07-222022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] addition age analysis assist C-index Clinical characteristics co-morbidity cohort study competing coronavirus disease Coronavirus disease 2019 COVID-19 cumulative cumulative incidence D-dimer death diagnosed with COVID-19 died dimer First wave global health Health healthcare hospital Hospital mortality Hospitalized hospitalized patient hospitalized patients identification in-hospital mortality incidence Italy lead lombardy majority marker medical staff Model moderate morbidities Mortality occurred outcome Patient patient records patients patients with COVID-19 performed Predictive Predictive value predictor primary endpoint Real-time PCR resources risk Sex statistical analyses study population survival Treatment was obtained [DOI] 10.1371/journal.pone.0264106 PMC 바로가기 [Article Type] Article